Breast Cancer

BREAST CARCINOMA IN-SITU AND HIGH RISK PATIENTS

There are two types non-invasive breast cancers recognised on the basis of histological pattern; ductal carcinoma in-situ (DCIS) and lobular carcinoma in-situ (LCIS). DCIS is the commoner form and makes up to 5% of symptomatic and 18% of screen detected cancers. In contrast, LCIS constitutes only 0.5% of symptomatic and approximately 1% of screen detected cancers.

Please choose from the following:

Ductal carcinoma in situ - Lobular carcinoma in situ - High risk patients

High Risk Factors for Breast Cancer.

There are a number of factors which have been identified as risk factors. Some of these are associated with a slightly elevated risk (< 2times) and are of no clinical significance requiring no action. Age at first pregnancy, history of breast feeding and diet are among low risk factors. There are only two factors which would suggest a need for clinical surveillance are history of certain types of benign breast disease and family history.

Benign Breast Disease
No Increased Risk Increased Risk but no clinical significance Increased Risk with clinical significance

Typical hyperplasia

Duct ectasia

Simple fibroadenomas

Apocrine metaplasia

Mastitis and adenosis

Palpable cysts

Moderate and florid hyperplasia

Complex fibroadenomas

Papillomas

Sclerosing adenosis

Atypical hyperplasia

Women with atypical hyperplasia are at significantly increased risk of developing breast cancer. There is a further interaction between atypical hyperplasia and family history. Women who have a first degree relative with breast cancer and atypical hyperplasia on breast biopsy have up to 30% absolute risk of developing breast cancer within next 15 - 20 years.

If you require further advice or information please contact the
Macmillan Breast Care Nurses, Hazel Ricard and Hilary Rickwood on 020 8565 5885

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